Voyant Bio

Overcoming resistance to immunotherapy

Resistance to cancer immunotherapy is orchestrated by highly localized ensembles of diverse immune cells within tumors. The Voyant platform leverages proprietary spatial mapping of tumors and machine learning to systematically discover otherwise inaccessible patterns of cellular ensembles which drive resistance to therapy. Our technology is uniquely suited to design therapeutic interventions that control cellular ensembles with precision to evade resistance. Partner with us to overcome resistance to immunotherapy.


Team

Assaf Magen, PhD
Founder & CEO
Computational Biology
Immuno-oncology

Dr. Magen pioneered integrative multi-modal discovery efforts to disentangle the multi-cellular interaction dynamics and molecular signals associated with response or resistance to ICB in liver cancer patients. He is well recognized in the field as a domain expert by top biopharma leaders.The team includes thought leaders across the biopharma/biotech software engineering, ML/AI engineering, data engineering, experimental design for effective inference, and immuno-oncology drug development.


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Blog post: Getting more from multimodal omics

Voyant Bio is Seeking a CTO/Founding Engineer



About Voyant Bio:
At Voyant Bio, we are on a mission to revolutionize drug discovery with an AI-native data analytics platform. A key challenge in drug discovery is making sense of multi-modal datasets and extracting biologically meaningful conclusions. Our platform aims to build best-in-class data analysis workflows to answer complex biological questions by talking to scientists. It’s not just another copilot; instead, it delivers relevant, best-in-class working solutions while you give it feedback. We are already in discussions with biopharma companies, and we are confident in our ability to secure paid contracts. Once we get venture funding, we will aim to accelerate our development and target smaller biotechs, adopting a vertical SaaS business model with licensing and usage-based fees.
Who We Are:
Our team is dedicated to transforming drug discovery and making a tangible impact in the world of life sciences. We bring a wealth of expertise and a deep understanding of the challenges and opportunities in this space. The founder (Assaf Magen, PhD) has extensive first-hand experience in life sciences (immuno-oncology) and cutting-edge computational biology data science applications. Our advisory team includes tenured professionals with extensive experience in software and data engineering, and applying AI/ML methods to large-scale biological studies.
The Role:
We are seeking an exceptional CTO/founding engineer to lead our technical efforts. This is a hands-on full-stack software engineering position which requires in-depth knowledge of modern ML/AI tools. Your expertise and leadership will be instrumental in building a robust, scalable, and user-friendly platform. We offer founding team level equity compensation for this role.
What You'll Do:
- Implement cutting-edge AI and ML techniques to power our analytics platform in a rapid agile development environment.
- Develop robust, scalable, and secure data infrastructure to handle diverse biological datasets.
- Build web applications with simple and intuitive UI.
- Work closely with the founding team to understand the scientific and user requirements, translating them into technical specifications and solutions.
- Drive the technical vision and strategy for the company, including platform architecture, tool selection, and development methodologies.
- Collaborate with stakeholders and partners to ensure the platform meets their needs and expectations.
- Lead and mentor a growing engineering team, fostering a culture of innovation, collaboration, and continuous improvement.
Typical Qualifications:
- A strong demonstrated expertise in all aspects of software engineering.
- Extensive experience building and scaling complex web applications or platforms.
- Proficiency in modern programming languages and frameworks (e.g., Python, React, Typescript).
- Familiarity with data infrastructure and management, including database design and data security.
- Experience delivering solutions leveraging public generative AI models.
- Experience with bioinformatics (e.g. multi-omic or spatial data analysis and method development) is highly desirable.
- Strong leadership and communication skills, with the ability to mentor and inspire a team.
- Passion for startups and a willingness to wear multiple hats.
- Interest in the life sciences domain and a desire to make a positive impact on drug discovery.
Fill in the form below or email us at [email protected].

Blog post: Getting more from multimodal omics

Blog post: Getting more from multi-omics

Team

Assaf Magen, PhD
Founder & CEO
Computational Biology

Dr. Magen pioneered such integrative multi-modal discovery efforts to disentangle the multi-cellular interaction dynamics and molecular signals associated with response or resistance to ICB in liver cancer patients, and he is well recognized in the field as a domain expert by top biopharma leaders. The team includes thought leaders across the biopharma/biotech software engineering, ML/AI engineering, data engineering, experimental design for effective inference, and immuno-oncology drug development.

Blog post: Getting more from multimodal omics

Voyant Bio: Revolutionizing Drug Discovery with AI and Spatial ProfilingThe Challenge: Unlocking the Power of Spatial Data for Therapeutic DiscoveryRecent advances in spatial profiling technologies have unveiled the intricate molecular landscapes of diseases, providing unprecedented resolution of tissue architecture and coordination. Highly multiplexed imaging, in situ sequencing, and spatial transcriptomics offer comprehensive molecular maps, holding great potential for therapeutic discovery. However, analyzing these massive, complex, and multidimensional datasets is a significant challenge, slowing down the translation of spatial data into new medicines. This is where Voyant Bio aims to make a difference.The Voyant Bio Solution: AI-Powered Tissue Mapping and AnalysisAs a leader in AI-powered tissue mapping and spatial omics, Voyant Bio is dedicated to helping biopharma partners overcome computational and analytical bottlenecks in spatial data analysis. By leveraging our advanced AI and machine learning capabilities, we streamline and accelerate the journey from spatial data to biological insights and drug targets.Our team's expertise lies in:
- AI Model Design and Training: We provide strategic advice on AI model design, training, and validation, ensuring that our partners' models are optimized for spatial data analysis.
- Automated Cell Classification: Using deep learning, we automatically classify immune cell types from images, revealing spatial patterns with predictive value.
- Rare Cell Subset Identification: Our generative modeling techniques help identify rare and novel cell subsets, even amid high background noise.
- Cell-Cell Interaction Analysis: By employing spatial graph neural networks, we infer cell-cell interactions, providing insights into cellular communication.
- Multi-Omics Data Integration: With our custom autoencoders, we integrate multi-omics data layers, combining diverse molecular information for comprehensive analysis.
- Advanced Visualization: Generative image modeling allows us to create advanced visualizations, offering a detailed view of tissue microenvironments.
For example, in a recent collaboration, we applied deep learning to multiplexed ion beam imaging data, successfully classifying over 50 immune cell types in lung tumors. This revealed distinct spatial patterns associated with immunotherapy response, demonstrating our ability to translate complex spatial data into actionable insights for drug discovery.Overcoming Bottlenecks with AI:- Handling Large Datasets: Advanced spatial profiling generates immense datasets. AI enables efficient analysis by processing large volumes of molecular and cellular data across millions of cells.
- Rare Cell Subset Identification: AI algorithms excel at identifying rare cell populations, even in crowded and complex tissue images, leading to the discovery of novel biomarkers.
- Image Denoising and Data Imputation: AI techniques enhance image quality by removing noise and imputing missing data values, improving the accuracy of downstream analysis.
- Integrating Heterogeneous Data: AI models can integrate diverse and disjointed data types, such as imaging, sequencing, and clinical data, into unified models for comprehensive analysis.
The Voyant Bio Team: A Fusion of ExpertiseOur team brings together a unique combination of interdisciplinary expertise:
- Machine Learning and AI: We have over 10 years of experience in optimizing AI techniques for spatial omics, single-cell genomics, and tissue imaging.
- Cancer Biology and Genomics: Our deep understanding of cancer biology and genomics enables us to interpret spatial data in the context of disease mechanisms.
- Tissue Imaging and Analysis: Our experts in tissue imaging and analysis ensure the optimal application of imaging-based spatial profiling techniques.
The Role of the CTO/Founding Engineer:To further strengthen our team, Voyant Bio is seeking an exceptional CTO/founding engineer to lead our technical efforts. This individual will play a pivotal role in building a robust, scalable, and user-friendly AI-native data analytics platform for drug discovery. The ideal candidate will have in-depth knowledge of modern ML/AI tools, full-stack software engineering expertise, and a passion for startups and life sciences. They will drive the technical vision, mentor a growing engineering team, and collaborate closely with the founding team to translate scientific requirements into technical solutions.Conclusion: Accelerating Therapeutic Discovery TogetherAt Voyant Bio, we are committed to partnerships that pave the way for transformative medicines. By combining our AI capabilities with our expertise in spatial profiling and analysis, we aim to unlock the full potential of spatial data for therapeutic discovery. Together with our partners and the right CTO/founding engineer, we strive to revolutionize drug discovery, improving patient care and outcomes.Let's embark on this exciting journey together, accelerating the translation of spatial profiling technologies into life-changing medicines.Get in touch with our founder, Assaf Magen, PhD (CEO, Voyant Bio) to learn more.

Job Posting: Senior Bioinformatician, Spatial Omics and Data AnalysisAbout Voyant Bio:At Voyant Bio, we are on a mission to revolutionize drug discovery by harnessing the power of AI and spatial omics. We recognize that spatial data holds the key to unlocking the complexities of tissue architecture and disease mechanisms. Our goal is to empower biopharma partners with advanced analytics, accelerating the journey from data to insights and, ultimately, life-changing medicines. As we continue to grow, we seek a talented and passionate senior bioinformatician to join our dynamic team.Role Overview:Job Title: Senior Bioinformatician, Spatial Omics and Data Analysis
Location: San Diego, CA
Employment Type: Full-Time
What You'll Do:Take a lead role in analyzing and interpreting spatial omics data, including highly multiplexed imaging, in situ sequencing, and spatial transcriptomics datasets.
Develop and apply advanced bioinformatics pipelines for the processing, integration, and analysis of spatial data, ensuring data quality and reproducibility.
Implement machine learning and AI techniques to identify novel cell subtypes, infer cell-cell interactions, and uncover spatial patterns associated with disease.
Collaborate closely with our AI team to integrate spatial data with other multi-omics data streams, leveraging the power of AI for comprehensive analysis.
Visualize and communicate complex spatial data effectively, creating intuitive representations of tissue microenvironments for internal stakeholders and clients.
Stay abreast of emerging technologies and advancements in spatial omics, evaluating their potential for therapeutic discovery and actively contributing to our technology roadmap.
Mentor and guide junior bioinformaticians, fostering a culture of continuous learning and knowledge sharing.
What You'll Bring:PhD in Bioinformatics, Computational Biology, Genomics, or a related field with a strong focus on spatial omics data analysis.
A minimum of 5 years of industry or academic post-doctoral experience in bioinformatics, with a proven track record of successful spatial data analysis projects.
Proficiency in programming languages commonly used in bioinformatics, such as Python, R, or similar, with experience in developing and optimizing data analysis pipelines.
Demonstrated expertise in machine learning and AI techniques, including experience with spatial data analysis tools and packages.
Strong background in genomics, transcriptomics, and multi-omics data integration, with a deep understanding of molecular biology and cellular processes.
Excellent communication and collaboration skills, with the ability to convey complex analytical concepts to both technical and non-technical stakeholders.
A passion for spatial omics and its potential to transform drug discovery, with a desire to stay at the forefront of this rapidly evolving field.
Why Join Us:At Voyant Bio, you'll be part of a dynamic and innovative team that is pushing the boundaries of AI and spatial omics. We offer a highly collaborative and inclusive work environment where your contributions will make a direct impact on accelerating therapeutic discovery. We value your professional growth and provide opportunities for mentorship and skill enhancement. Join us on this exciting journey as we strive to revolutionize drug discovery and improve patient outcomes worldwide.How to Apply:If you are excited about the prospect of joining a forward-thinking company at the intersection of AI and spatial omics, we want to hear from you! Please submit your resume and a cover letter highlighting your relevant experience and your passion for this field to [email protected]. We look forward to receiving your application and the potential of welcoming you to our dynamic team!Let's embark on this exciting journey together, as we unlock the spatial secrets of disease and create a brighter future for patients worldwide.Join the Voyant Bio Revolution!Get in touch with our founder, Assaf Magen, PhD (CEO, Voyant Bio) to learn more.

Unlocking the Power of AI in Biomedical Discovery: Revolutionizing Therapeutic DevelopmentIntroduction: Accelerating the Journey from Data to Life-Changing MedicinesIn the realm of biomedical research, data is pivotal. It holds the key to unlocking discoveries and creating therapies that transform lives. However, generating and analyzing data is often a slow and challenging process. That's where we step in, aiming to revolutionize the landscape of biomedical research.Our Vision: Empowering Researchers, Accelerating DiscoveryWe firmly believe that AI has the potential to revolutionize biomedical discovery. By harnessing cutting-edge artificial intelligence and machine learning technologies, we aim to drastically reduce the time and effort required for data collection and analysis. With our innovative approach, we are transforming the way researchers work, empowering them to maximize the value of their data and accelerate the pace of therapeutic development.Our Team: A Fusion of ExpertiseOur team is comprised of dedicated individuals with a shared passion for pushing the boundaries of biomedical research and education. We deeply understand the challenges faced by researchers and are committed to offering transformative solutions. Our co-founders are renowned leaders, bringing expertise in functional genomics, cancer biology, biostatistics, and data science. They are joined by a diverse group of professionals passionate about innovation and with a deep understanding of biology, computation, and software engineering.Our Platform: Unlocking the Full Potential of DataOur AI-powered platform is designed to revolutionize how researchers generate, analyze, and interpret data. By leveraging advanced machine learning techniques, we enable researchers to:Synthesize and Interpret Vast Datasets: Our platform integrates diverse data streams, including genomic, transcriptomic, and clinical information, providing a comprehensive understanding of biological systems.
Accelerate Hypothesis Testing: AI-driven analysis facilitates rapid hypothesis testing, enabling data-driven decisions and exploration, reducing time wasted on fruitless pursuits.
Uncover Deep Insights: Our advanced analytics reveal hidden patterns and insights, leading to novel discoveries and enhancing our understanding of biological mechanisms.
Enhance Data Quality: We ensure data integrity and reproducibility, improving the reliability of downstream analysis and decision-making.
Visualize Complex Information: Intuitive data visualizations make complex biological insights accessible, fostering collaboration and strategic thinking.
Our Impact: Transforming Therapeutic DevelopmentOur AI-driven approach is making a significant impact on therapeutic development:Efficiency and Speed: Researchers can now generate and analyze data faster, reducing the time from hypothesis to discovery, and accelerating the journey towards clinical applications.
Cost Savings: By minimizing the need for extensive lab experiments and manual data analysis, we reduce personnel and material costs, making therapeutic development more efficient and accessible.
Enhanced Decision-Making: Comprehensive and accurate data insights improve decision-making, reducing the risk of costly mistakes and increasing the success rate of therapeutic candidates.
Personalized Medicine: Our platform enables the development of targeted therapies, tailored to individual genetic variations and disease mechanisms.
Join Us on This Exciting Journey:We are seeking talented individuals passionate about revolutionizing biomedical discovery. If you have expertise in AI, machine learning, biology, or software engineering, and you want to be part of a dynamic team making a real impact, we want to hear from you. Together, we can unlock the full potential of AI in biomedical research and create a brighter future for patients worldwide.Let's embark on this exciting journey, as we pave the way for faster, more efficient, and transformative therapeutic development, powered by AI. Join us in revolutionizing the future of healthcare, as we strive to turn data into life-changing medicines.Join the Revolution!Our innovative AI-powered platform is designed to revolutionize how researchers interpret data, accelerating the journey from hypothesis to discovery. With our advanced machine learning techniques, we enable researchers to uncover hidden patterns, leading to novel insights and a deeper understanding of biological mechanisms.By joining our dynamic team, you will be part of a passionate group dedicated to transforming biomedical research. Together, we will empower researchers, accelerate discovery, and ultimately, improve patient outcomes. Let's unlock the full potential of AI in biomedical discovery and create a brighter future for those in need.Let's embark on this exciting journey, as we pioneer the use of AI in therapeutic development, setting a new standard for efficient, effective, and personalized medicine.Revolutionizing the future of biomedical discovery, our AI-powered platform transforms how researchers generate, analyze, and interpret data. By leveraging cutting-edge machine learning, we enhance hypothesis testing, reveal hidden insights, and improve data quality.Join us on this exciting journey, as we empower researchers with the tools to accelerate the pace of discovery and improve patient outcomes on a global scale. Together, let's unlock the full potential of AI, creating a brighter future for biomedical research and those it serves.Get in touch with our founder, Assaf Magen, PhD (CEO, Voyant Bio) to learn more.

Voyant Bio's AI-native data analytics platform revolutionizes drug discovery by empowering scientists to interrogate diverse data types and modalities, uncovering novel insights, and accelerating the journey from biological insights to life-changing treatments. Here's how Voyant Bio's platform addresses the challenges and limitations described in the publication and expands the capabilities of current analysis strategies:Data Integration:Voyant Bio's platform enables seamless integration of multi-omics and multi-modal data, including histology, genomics, single-cell profiling, and spatial profiling data. This comprehensive view of the tumor microenvironment facilitates the identification of key biological insights that drive response to immunotherapies.
Our platform supports various data formats and can integrate data from different sources, making it easy for researchers to aggregate and analyze data from multiple experiments or studies.
Advanced Analysis Capabilities:Voyant Bio offers a wide range of advanced analysis tools, such as clustering analysis, differential expression analysis, and ligand-receptor interaction analysis, enabling scientists to gain deeper insights into the complex biology of HCC and other diseases.
Our platform provides interactive visualization tools that allow scientists to explore and interpret data in real time, facilitating a deeper understanding of the immune landscape.
With Voyant Bio, scientists can go beyond standard analysis techniques and leverage cutting-edge machine learning and artificial intelligence algorithms to uncover hidden patterns and relationships in the data.
User-Friendly Interface:Voyant Bio's platform is designed with a user-friendly interface, allowing scientists to ask complex biological questions using plain English. Our AI developer handles the coding, making it accessible to users with varying levels of computational expertise.
Our platform provides an intuitive drag-and-drop interface for building analysis workflows, making it easy for users to customize their analysis pipelines.
We also offer a comprehensive knowledge base and tutorials to help users get started and make the most of our platform.
Scalability and Flexibility:Voyant Bio's platform is built with scalability and flexibility in mind. It can easily adapt to new data types and technologies, ensuring that your analysis workflows stay up-to-date with the rapidly evolving life sciences landscape.
Our platform offers customizable solutions tailored to the specific needs of your research. Whether you're working with bulk or single-cell data, our platform can handle it.
With Voyant Bio, you can future-proof your drug discovery efforts by leveraging the latest advancements in data analytics and machine intelligence.
Collaboration and Data Sharing:Voyant Bio facilitates collaboration and data sharing among researchers, enabling efficient knowledge sharing and accelerating the discovery process.
Our platform provides secure collaboration features, allowing researchers to work together seamlessly, regardless of their geographical location.
With Voyant Bio, you can easily share insights, analysis workflows, and data visualizations with your colleagues and partners, fostering a culture of collaboration and innovation.
Data Security and Privacy:We take data security and privacy extremely seriously. Our platform employs robust security measures, including encryption, access controls, and data protection protocols, to safeguard sensitive data.
Voyant Bio ensures that your data remains confidential and is only accessible to authorized users, giving you peace of mind.
Our platform is designed to comply with regulatory requirements, such as GDPR and HIPAA, ensuring that your data handling practices meet the highest standards.
With Voyant Bio's AI-native data analytics platform, scientists can perform all the analyses described in the publication and more, with increased efficiency and speed. Our platform enables users to explore and visualize data in new and intuitive ways, uncovering hidden patterns and relationships that drive treatment response. By leveraging the power of AI and advanced analysis techniques, Voyant Bio accelerates the journey from biological insights to life-changing treatments, bringing hope to patients worldwide.Get in touch with our founder, Assaf Magen, PhD (CEO, Voyant Bio) to learn more.

Voyant Bio is thrilled to introduce its Founder and CEO, Dr. Assaf Magen, a visionary leader and entrepreneur in the field of computational biology and cancer immunology. With a strong foundation in biomathematics, bioinformatics, and computational biology, Dr. Magen brings a unique blend of expertise to the forefront.Prior to founding Voyant Bio, Dr. Magen served as an Assistant Professor and Computational Immunologist at the renowned Mount Sinai Health System. During his tenure, he led computational efforts for a post-IND anti-PD-1 neoadjuvant trial in hepatocellular carcinoma, exploring mechanisms of drug activity. His groundbreaking research, published in Nature Medicine, identified novel immune cell interactions that may hold the key to enhancing immunotherapy responses.Dr. Magen's academic journey began at the University of Maryland, where he obtained his Master of Science and Doctor of Philosophy degrees in Biomathematics, Bioinformatics, and Computational Biology. His dedication to his field is evident through his numerous publications, presentations at prestigious conferences, and leadership roles within the NIH community.As an entrepreneur, Dr. Magen is on a mission to revolutionize drug discovery with Voyant Bio's AI-native data analytics platform. By empowering scientists to ask complex biological questions in plain English, the platform delivers interpretable, data-driven answers and visualizations instantly.In addition to his role at Voyant Bio, Dr. Magen is the Consulting Director at Magen Consulting Group, where he provides strategic advice and bioinformatic analytical consulting services to academic and industry partners.Dr. Magen's expertise spans single-cell transcriptomics, proteomics, epigenomics, and T cell receptor repertoire analysis. His leadership and mentorship extend beyond his professional pursuits, as he actively engages in knowledge-sharing within the scientific community.With a passion for innovation and a commitment to making a tangible impact in life sciences, Dr. Magen is an invaluable asset to the field of computational biology and cancer immunology.

At Voyant Bio, we are dedicated to addressing the challenges highlighted in the article and revolutionizing cancer precision medicine through our innovative platform. Our advanced AI-driven solutions provide powerful tools for multi-omics analysis, enabling biopharma partners to accelerate drug discovery and development.Here's how Voyant Bio solves the challenges presented in the article:Multi-Omics Data Integration: Our platform is designed to seamlessly integrate multi-omics data, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics. By combining these diverse data streams, we offer a holistic view of tumor behavior and biology, enabling a deeper understanding of oncogenesis and tumor heterogeneity.
AI-Driven Analysis: We harness the power of AI, specifically deep learning (DL), to analyze complex and heterogeneous multi-omics data. Our advanced AI algorithms can identify non-linear and high-dimensional relationships within the data, uncovering valuable insights that may be missed by traditional methods. This AI-driven approach enhances our understanding of cancer biology and facilitates the discovery of novel drug targets and biomarkers.
Precision Medicine: Voyant Bio's platform is tailored for cancer precision medicine initiatives. Our AI algorithms integrate data from multiple platforms, including genomics, epigenomics, transcriptomics, and more, to precisely identify cancer subtypes and provide robust predictions of cancer prognosis and treatment responses. This precision enables the development of tailored therapies for individual patients, improving clinical outcomes.
Early Cancer Screening and Diagnosis: Our AI-based multi-omics technologies are applied to early cancer screening and diagnosis, improving accuracy and timely intervention. By analyzing multi-omics data, we can detect cancer at its earliest stages, when treatment options are often more effective and curative.
Response Assessment and Prognosis Prediction: Voyant Bio's platform goes beyond initial diagnosis, providing valuable insights for response assessment and prognosis prediction. Our AI algorithms integrate clinical, molecular, and multi-omics data to predict treatment responses and offer prognostic information, guiding clinicians in making informed decisions and optimizing therapeutic strategies.
Addressing Challenges: We recognize the challenges presented in the article, including the complexity and heterogeneity of multi-omics data. Our AI approaches are specifically designed to tackle these complexities, providing biopharma partners with actionable insights. We continuously push the boundaries of AI and spatial omics to overcome these challenges and drive innovation in cancer precision medicine.
At Voyant Bio, we are committed to transforming drug discovery and development through our AI-driven spatial omics platform. By integrating multi-omics data and leveraging the power of AI, we empower our biopharma partners to accelerate the journey toward life-changing medicines for cancer patients. Our advanced analytics provide valuable insights, improve clinical decision-making, and ultimately, enhance patient outcomes.With Voyant Bio's cutting-edge platform, the future of cancer precision medicine is within reach.Get in touch with our founder, Assaf Magen, PhD (CEO, Voyant Bio) to learn more.